ea0026p16 | Adrenal cortex | ECE2011
Duparc Celine
, Moreau Lucile
, Perraudin Veronique
, Gobet Francoise
, Meatchi Tchao
, Plouin Pierre-Francois
, Zennaro Maria-Christina
, Louiset Estelle
, Lefebvre Herve
We have shown that 5-hydroxytryptamine (5-HT) receptor type 4 (5-HT4R) agonists stimulate aldosterone production in patients with aldosterone-producing adenoma (APA). Moreover, 5-HT-positive cells were observed in APA tissues and 5-HT4R mRNAs were markedly overexpressed in APAs in comparison with normal adrenals. All these results suggested that 5-HT produced by adrenal mast cells could be involved in the physiopathology of APAs. The aim of this work was to investigate the rol...